Transcription termination factor 4, mitochondrial (MTERF4)
Homo sapiens — UniProt Q7Z6M4
Data last refreshed: (UniProt release unknown)
Key facts
Transcription termination factor 4, mitochondrial (MTERF4) is a protein from Homo sapiens identified by UniProt accession Q7Z6M4, 381 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q7Z6M4; gene symbol MTERF4.
- Organism: Homo sapiens.
- Length: 381 amino acids.
- Top disease associations (Open Targets): appendicular lean mass, vital capacity and BMI-adjusted hip circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription termination factor 4, mitochondrial |
|---|---|
| UniProt accession | Q7Z6M4 |
| Gene | MTERF4 |
| Organism | Homo sapiens |
| Length | 381 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.21
- vital capacity · score 0.21
- BMI-adjusted hip circumference · score 0.19
- body height · score 0.18
- forced expiratory volume · score 0.17
- body fat percentage · score 0.11
- sitting height measurement · score 0.08
- retinitis pigmentosa 71 · score 0.03
- retinitis pigmentosa · score 0.03
- Vertigo · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6M4-F1 | alphafold | PREDICTED | 76.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6M4.
Amino-acid sequence (381 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTERF4?
The strongest Open Targets associations for MTERF4 are appendicular lean mass, vital capacity, BMI-adjusted hip circumference, body height and forced expiratory volume.
How long is the MTERF4 protein?
The Homo sapiens MTERF4 protein (UniProt Q7Z6M4) is 381 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6M4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6M4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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