Transcription factor AP-2-delta (TFAP2D)
Homo sapiens — UniProt Q7Z6R9
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor AP-2-delta (TFAP2D) is a protein from Homo sapiens identified by UniProt accession Q7Z6R9, 452 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q7Z6R9; gene symbol TFAP2D.
- Organism: Homo sapiens.
- Length: 452 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, body mass index and age at first sexual intercourse measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor AP-2-delta |
|---|---|
| UniProt accession | Q7Z6R9 |
| Gene | TFAP2D |
| Organism | Homo sapiens |
| Length | 452 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.44
- body mass index · score 0.41
- age at first sexual intercourse measurement · score 0.40
- diastolic blood pressure · score 0.40
- refractive error · score 0.34
- Myopia · score 0.30
- age at onset · score 0.29
- self reported educational attainment · score 0.21
- glioblastoma multiforme · score 0.18
- cystatin C measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6R9-F1 | alphafold | PREDICTED | 62.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6R9.
Amino-acid sequence (452 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TFAP2D?
The strongest Open Targets associations for TFAP2D are systolic blood pressure, body mass index, age at first sexual intercourse measurement, diastolic blood pressure and refractive error.
How long is the TFAP2D protein?
The Homo sapiens TFAP2D protein (UniProt Q7Z6R9) is 452 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6R9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6R9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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