Patatin-like phospholipase domain-containing protein 5 (PNPLA5)
Homo sapiens — UniProt Q7Z6Z6
Data last refreshed: (UniProt release unknown)
Key facts
Patatin-like phospholipase domain-containing protein 5 (PNPLA5) is a protein from Homo sapiens identified by UniProt accession Q7Z6Z6, 429 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q7Z6Z6; gene symbol PNPLA5.
- Organism: Homo sapiens.
- Length: 429 amino acids.
- Top disease associations (Open Targets): gut microbiome measurement, sleep measurement and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Patatin-like phospholipase domain-containing protein 5 |
|---|---|
| UniProt accession | Q7Z6Z6 |
| Gene | PNPLA5 |
| Organism | Homo sapiens |
| Length | 429 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.23
- sleep measurement · score 0.08
- self reported educational attainment · score 0.07
- glycoprotein storage disease · score 0.05
- neuronal ceroid lipofuscinosis 1 · score 0.04
- hemoglobin H disease · score 0.04
- hemoglobin C-beta-thalassemia syndrome · score 0.04
- central nervous system cancer · score 0.04
- combined immunodeficiency due to OX40 deficiency · score 0.04
- familial isolated congenital asplenia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6Z6-F1 | alphafold | PREDICTED | 81.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6Z6.
Amino-acid sequence (429 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PNPLA5?
The strongest Open Targets associations for PNPLA5 are gut microbiome measurement, sleep measurement, self reported educational attainment, glycoprotein storage disease and neuronal ceroid lipofuscinosis 1.
How long is the PNPLA5 protein?
The Homo sapiens PNPLA5 protein (UniProt Q7Z6Z6) is 429 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6Z6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6Z6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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