YTH domain-containing family protein 3 (YTHDF3)
Homo sapiens — UniProt Q7Z739
Data last refreshed: (UniProt release unknown)
Key facts
YTH domain-containing family protein 3 (YTHDF3) is a protein from Homo sapiens identified by UniProt accession Q7Z739, 585 residues long. MolForge cross-references it against 0 known binders and 162 disease associations.
- UniProt accession: Q7Z739; gene symbol YTHDF3.
- Organism: Homo sapiens.
- Length: 585 amino acids.
- Top disease associations (Open Targets): myocardial infarction, diet measurement and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | YTH domain-containing family protein 3 |
|---|---|
| UniProt accession | Q7Z739 |
| Gene | YTHDF3 |
| Organism | Homo sapiens |
| Length | 585 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (162)
Diseases linked to this target (Open Targets).
- myocardial infarction · score 0.26
- diet measurement · score 0.22
- systolic blood pressure · score 0.22
- cigarettes per day measurement · score 0.20
- C-reactive protein measurement · score 0.18
- body mass index · score 0.17
- triglyceride measurement · score 0.17
- body weight · score 0.16
- diastolic blood pressure · score 0.16
- hepatocellular carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z739-F1 | alphafold | PREDICTED | 60.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z739.
Amino-acid sequence (585 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with YTHDF3?
The strongest Open Targets associations for YTHDF3 are myocardial infarction, diet measurement, systolic blood pressure, cigarettes per day measurement and C-reactive protein measurement.
How long is the YTHDF3 protein?
The Homo sapiens YTHDF3 protein (UniProt Q7Z739) is 585 amino acids long.
Browse: Targets: Y · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z739 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z739 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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