Maestro heat-like repeat-containing protein family member 2B (MROH2B)

Homo sapiens — UniProt Q7Z745

Gene: MROH2BHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Maestro heat-like repeat-containing protein family member 2B (MROH2B) is a protein from Homo sapiens identified by UniProt accession Q7Z745, 1585 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

UniProt accession: Q7Z745; gene symbol MROH2B.
Organism: Homo sapiens.
Length: 1585 amino acids.
Top disease associations (Open Targets): complement component C7 measurement, blood protein measurement and protein measurement.
3D structure: AlphaFold model available.

Target properties

Protein name	Maestro heat-like repeat-containing protein family member 2B
UniProt accession	Q7Z745
Gene	MROH2B
Organism	Homo sapiens
Length	1585 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

complement component C7 measurement · score 0.15
blood protein measurement · score 0.06
protein measurement · score 0.06
cerebrospinal fluid biomarker measurement · score 0.05
Duchenne muscular dystrophy · score 0.04
DNA repair protein rad51 homolog 1 measurement · score 0.04
experimental autoimmune encephalomyelitis · score 0.04
pulmonary tuberculosis · score 0.02
myeloid sarcoma · score 0.01
Autoimmune Hepatitis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z745-F1	alphafold	PREDICTED	84.74	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z745.

Amino-acid sequence (1585 residues)

MTLSTEESIE MFGDINLTLG MLNKEDIVNK EDIYSHLTSV IQNTDILDDA IVQRLIYYAS KDMRDNNMLR EIRMLAGEVL VSLAAHDFNS VMYEVQSNFR ILELPDEFVV LALAELATSY VSQSIPFMMM TLLTMQTMLR LAEDERMKGT FCIALEKFSK AIYKYVNHWR DFPYPRLDAN RLSDKIFMLF WYIMEKWAPL ASPMQTLSIV KAHGPTVSLL LHREDFRGYA LGQVPWLLNQ YKDKEIDFHV TQSLKQILTA AVLYDIGLPR SLRRSIFINL LQQICRAPEP PVKENEMKAS SCFLILAHSN PGELMEFFDE QVRSNNEAIR VGILTLLRLA VNADEPRLRD HIISIERTVK IVMGDLSTKV RNSVLLLIQT MCEKSYIEAR EGWPLIDYVF SQFATLNRNL EKPVKTNFHE NEKEEESVRE TSLEVLKTLD PLVIGMPQVL WPRILTFVVP AEYTEALEPL FSIIRILIMA EEKKQHSAKE STALVVSTGA VKLPSPQQLL ARLLVISMPA SLGELRGAGA IGLLKILPEI IHPKLVDLWK TRLPELLQPL EGKNISTVLW ETMLLQLLKE SLWKISDVAW TIQLTQDFKQ QMGSYSNNST EKKFLWKALG TTLACCQDSD FVNSQIKEFL TAPNQLGDQR QGITSILGYC AENHLDIVLK VLKTFQNQEK FFMNRCKSLF SGKKSLTKTD VMVIYGAVAL HAPKKQLLSR LNQDIISQVL SLHGQCSQVL GMSVMNKDMD LQMSFTRSIT EIGIAVQDAE DQGFQFSYKE MLIGYMLDFI RDEPLDSLAS PIRWKALIAI RYLSKLKPQL SLQDHLNILE ENIRRLLPLP PLENLKSEGQ TDKDKEHIQF LYERSMDALG KLLKTMMWDN VNAEDCQEMF NLLQMWLVSQ KEWERERAFQ ITAKVLTNDI EAPENFKIGS LLGLLAPHSC DTLPTIRQAA ASSTIGLFYI KGIHLEVERL QGLQEGLESD DVQVQIKISS KIAKIVSKFI PNEEILMFLE EMLDGLESLN PTCTKACGIW MITVLKQQGA ALEDQLLEIL GTIYHHMPVL RQKEESFQFI LEAISQIASF HMDTVVVNLL QKPLPFDRDT KTLWKALAEK PASSGKLLQA LIDKLETELE DDIARVEAIS VACAMYEVIS MGTSVTGLYP ELFTLLLKLV SCTLGQKMLT CPWSHRRHVM QQGEQQQIPD PCRLSTATLK CLQAQAMREG LAKESDEGDN LWTLLSSPST HHIGVCSLAR SMAVWQHGVI LDIMEQLLSS LTSSSENYRI TGAAFFSELM KEPILWKHGN LRNVLILMDQ SAWDSNATLR QMAIRGLGNT ASGAPHKVKK HKQLMLESII RGLYHLARTE VVCESLKALK KILELLTDRD VSFYFKEIVL QTRTFFEDEQ DDVRLTAIFL FEDLAPLTGR RWKIFFAEEI KKSLISFLLH LWDPNPKIGV ACRDVLMVCI PFLGLQELYG VLDRLLDQDL PRARDFYRQF CVKLAKKNQE ILWILHTHSF TFFTSTWEVI RSAAVKLTDA VVLNLTSQYV ELLDREQLTT RLQALRQDPC ISVQRAAEAA LQTLLRRCKE TSIPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with MROH2B?

The strongest Open Targets associations for MROH2B are complement component C7 measurement, blood protein measurement, protein measurement, cerebrospinal fluid biomarker measurement and Duchenne muscular dystrophy.

How long is the MROH2B protein?

The Homo sapiens MROH2B protein (UniProt Q7Z745) is 1585 amino acids long.

Browse: Targets: M · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q7Z745 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q7Z745 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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