Keratin, type II cytoskeletal 1b (KRT77)
Homo sapiens — UniProt Q7Z794
Data last refreshed: (UniProt release unknown)
Key facts
Keratin, type II cytoskeletal 1b (KRT77) is a protein from Homo sapiens identified by UniProt accession Q7Z794, 578 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q7Z794; gene symbol KRT77.
- Organism: Homo sapiens.
- Length: 578 amino acids.
- Top disease associations (Open Targets): head and neck squamous cell carcinoma, ovarian cancer and clear cell renal carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin, type II cytoskeletal 1b |
|---|---|
| UniProt accession | Q7Z794 |
| Gene | KRT77 |
| Organism | Homo sapiens |
| Length | 578 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.18
- ovarian cancer · score 0.18
- clear cell renal carcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- eosinophil count · score 0.10
- isolated hyperchlorhidrosis · score 0.04
- psoriasis · score 0.04
- hearing loss-familial salivary gland insensitivity to aldosterone syndrome · score 0.04
- Crohn's disease · score 0.03
- rosacea · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z794-F1 | alphafold | PREDICTED | 66.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z794.
Amino-acid sequence (578 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT77?
The strongest Open Targets associations for KRT77 are head and neck squamous cell carcinoma, ovarian cancer, clear cell renal carcinoma, breast adenocarcinoma and eosinophil count.
How long is the KRT77 protein?
The Homo sapiens KRT77 protein (UniProt Q7Z794) is 578 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z794 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z794 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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