Cytoplasmic tRNA 2-thiolation protein 1 (CTU1)
Homo sapiens — UniProt Q7Z7A3
Data last refreshed: (UniProt release unknown)
Key facts
Cytoplasmic tRNA 2-thiolation protein 1 (CTU1) is a protein from Homo sapiens identified by UniProt accession Q7Z7A3, 348 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q7Z7A3; gene symbol CTU1.
- Organism: Homo sapiens.
- Length: 348 amino acids.
- Top disease associations (Open Targets): blood protein measurement, FEV/FVC ratio and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytoplasmic tRNA 2-thiolation protein 1 |
|---|---|
| UniProt accession | Q7Z7A3 |
| Gene | CTU1 |
| Organism | Homo sapiens |
| Length | 348 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.28
- FEV/FVC ratio · score 0.27
- neurodegenerative disease · score 0.26
- sialic acid-binding Ig-like lectin 9 measurement · score 0.13
- Crigler-Najjar syndrome type 2 · score 0.04
- transient familial neonatal hyperbilirubinemia · score 0.04
- neoplasm · score 0.02
- breast cancer · score 0.02
- calf circumference measurement · score 0.01
- cervical adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7A3-F1 | alphafold | PREDICTED | 84.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7A3.
Amino-acid sequence (348 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CTU1?
The strongest Open Targets associations for CTU1 are blood protein measurement, FEV/FVC ratio, neurodegenerative disease, sialic acid-binding Ig-like lectin 9 measurement and Crigler-Najjar syndrome type 2.
How long is the CTU1 protein?
The Homo sapiens CTU1 protein (UniProt Q7Z7A3) is 348 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7A3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7A3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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