PX domain-containing protein kinase-like protein (PXK)
Homo sapiens — UniProt Q7Z7A4
Data last refreshed: (UniProt release unknown)
Key facts
PX domain-containing protein kinase-like protein (PXK) is a protein from Homo sapiens identified by UniProt accession Q7Z7A4, 578 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.
- UniProt accession: Q7Z7A4; gene symbol PXK.
- Organism: Homo sapiens.
- Length: 578 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Alzheimer disease and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PX domain-containing protein kinase-like protein |
|---|---|
| UniProt accession | Q7Z7A4 |
| Gene | PXK |
| Organism | Homo sapiens |
| Length | 578 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (76)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- Alzheimer disease · score 0.46
- multiple sclerosis · score 0.46
- Parkinson disease · score 0.46
- lysosomal storage disease · score 0.46
- low density lipoprotein cholesterol measurement · score 0.34
- aspartate aminotransferase measurement · score 0.34
- total cholesterol measurement · score 0.32
- systemic scleroderma · score 0.30
- sex hormone-binding globulin measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7A4-F1 | alphafold | PREDICTED | 85.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7A4.
Amino-acid sequence (578 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PXK?
The strongest Open Targets associations for PXK are neurodegenerative disease, Alzheimer disease, multiple sclerosis, Parkinson disease and lysosomal storage disease.
How long is the PXK protein?
The Homo sapiens PXK protein (UniProt Q7Z7A4) is 578 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7A4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7A4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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