Glucosaminyl-phosphatidylinositol-acyltransferase PIGW (PIGW)
Homo sapiens — UniProt Q7Z7B1
Data last refreshed: (UniProt release unknown)
Key facts
Glucosaminyl-phosphatidylinositol-acyltransferase PIGW (PIGW) is a protein from Homo sapiens identified by UniProt accession Q7Z7B1, 504 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: Q7Z7B1; gene symbol PIGW.
- Organism: Homo sapiens.
- Length: 504 amino acids.
- Top disease associations (Open Targets): hyperphosphatasia-intellectual disability syndrome, genetic disorder and hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Glucosaminyl-phosphatidylinositol-acyltransferase PIGW |
|---|---|
| UniProt accession | Q7Z7B1 |
| Gene | PIGW |
| Organism | Homo sapiens |
| Length | 504 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- hyperphosphatasia-intellectual disability syndrome · score 0.65
- genetic disorder · score 0.41
- hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency · score 0.40
- Global developmental delay · score 0.27
- Abnormal skeletal morphology · score 0.27
- Cleft palate · score 0.27
- macrophage inflammatory protein 1b measurement · score 0.10
- Red cell distribution width · score 0.07
- body weight · score 0.05
- body fat percentage · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7B1-F1 | alphafold | PREDICTED | 87.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7B1.
Amino-acid sequence (504 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIGW?
The strongest Open Targets associations for PIGW are hyperphosphatasia-intellectual disability syndrome, genetic disorder, hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency, Global developmental delay and Abnormal skeletal morphology.
How long is the PIGW protein?
The Homo sapiens PIGW protein (UniProt Q7Z7B1) is 504 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7B1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7B1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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