Beta-defensin 132 (DEFB132)
Homo sapiens — UniProt Q7Z7B7
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 132 (DEFB132) is a protein from Homo sapiens identified by UniProt accession Q7Z7B7, 95 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q7Z7B7; gene symbol DEFB132.
- Organism: Homo sapiens.
- Length: 95 amino acids.
- Top disease associations (Open Targets): head and neck squamous cell carcinoma, gastric adenocarcinoma and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 132 |
|---|---|
| UniProt accession | Q7Z7B7 |
| Gene | DEFB132 |
| Organism | Homo sapiens |
| Length | 95 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.15
- gastric adenocarcinoma · score 0.14
- breast adenocarcinoma · score 0.10
- Autosomal dominant striatal neurodegeneration · score 0.04
- breast carcinoma · score 0.04
- carcinoma of liver and intrahepatic biliary tract · score 0.02
- breast ductal carcinoma in situ · score 0.01
- breast cancer · score 0.01
- invasive breast ductal carcinoma · score 0.01
- prostate adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7B7-F1 | alphafold | PREDICTED | 70.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7B7.
Amino-acid sequence (95 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB132?
The strongest Open Targets associations for DEFB132 are head and neck squamous cell carcinoma, gastric adenocarcinoma, breast adenocarcinoma, Autosomal dominant striatal neurodegeneration and breast carcinoma.
How long is the DEFB132 protein?
The Homo sapiens DEFB132 protein (UniProt Q7Z7B7) is 95 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7B7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7B7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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