Beta-defensin 128 (DEFB128)
Homo sapiens — UniProt Q7Z7B8
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 128 (DEFB128) is a protein from Homo sapiens identified by UniProt accession Q7Z7B8, 93 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q7Z7B8; gene symbol DEFB128.
- Organism: Homo sapiens.
- Length: 93 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, cutaneous melanoma and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 128 |
|---|---|
| UniProt accession | Q7Z7B8 |
| Gene | DEFB128 |
| Organism | Homo sapiens |
| Length | 93 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- cutaneous melanoma · score 0.23
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.05
- partial chromosome Y deletion · score 0.05
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.05
- spermatogenic failure 61 · score 0.05
- spermatogenic failure 55 · score 0.05
- spermatogenic failure 3 · score 0.05
- spermatogenic failure 59 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7B8-F1 | alphafold | PREDICTED | 69.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7B8.
Amino-acid sequence (93 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB128?
The strongest Open Targets associations for DEFB128 are neurodegenerative disease, cutaneous melanoma, azoospermia, male infertility with teratozoospermia due to single gene mutation and partial chromosome Y deletion.
How long is the DEFB128 protein?
The Homo sapiens DEFB128 protein (UniProt Q7Z7B8) is 93 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7B8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7B8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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