Transcription initiation factor TFIID subunit 8 (TAF8)
Homo sapiens — UniProt Q7Z7C8
Data last refreshed: (UniProt release unknown)
Key facts
Transcription initiation factor TFIID subunit 8 (TAF8) is a protein from Homo sapiens identified by UniProt accession Q7Z7C8, 310 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q7Z7C8; gene symbol TAF8.
- Organism: Homo sapiens.
- Length: 310 amino acids.
- Top disease associations (Open Targets): Neurodevelopmental disorder, Microcephaly and Partial agenesis of the corpus callosum.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription initiation factor TFIID subunit 8 |
|---|---|
| UniProt accession | Q7Z7C8 |
| Gene | TAF8 |
| Organism | Homo sapiens |
| Length | 310 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- Neurodevelopmental disorder · score 0.47
- Microcephaly · score 0.34
- Partial agenesis of the corpus callosum · score 0.34
- Severe global developmental delay · score 0.34
- neurodegenerative disease · score 0.34
- lymphocyte count · score 0.25
- platelet count · score 0.23
- leukocyte count · score 0.22
- mean corpuscular volume · score 0.22
- platelet crit · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7C8-F1 | alphafold | PREDICTED | 73.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7C8.
Amino-acid sequence (310 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TAF8?
The strongest Open Targets associations for TAF8 are Neurodevelopmental disorder, Microcephaly, Partial agenesis of the corpus callosum, Severe global developmental delay and neurodegenerative disease.
How long is the TAF8 protein?
The Homo sapiens TAF8 protein (UniProt Q7Z7C8) is 310 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7C8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7C8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.