About KH homology domain-containing protein 4
KH homology domain-containing protein 4 (KHDC4) is a protein
from Homo sapiens identified by UniProt accession
Q7Z7F0, 614 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | KH homology domain-containing protein 4 |
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| UniProt accession | Q7Z7F0 |
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| Gene | KHDC4 |
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| Organism | Homo sapiens |
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| Length | 614 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.12
- sex hormone-binding globulin measurement · score 0.12
- oral squamous cell carcinoma · score 0.08
- body mass index · score 0.06
- inflammatory bowel disease · score 0.04
- Crohn's disease · score 0.03
- vitamin D measurement · score 0.03
- Parkinson disease · score 0.02
- reticulocyte measurement · score 0.02
- cancer · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z7F0-F1 | alphafold | PREDICTED | 62.25 | — |
Amino-acid sequence (614 residues)
MSAGSATHPG AGGRRSKWDQ PAPAPLLFLP PAAPGGEVTS SGGSPGGTTA APSGALDAAA AVAAKINAML MAKGKLKPTQ NASEKLQAPG KGLTSNKSKD DLVVAEVEIN DVPLTCRNLL TRGQTQDEIS RLSGAAVSTR GRFMTTEEKA KVGPGDRPLY LHVQGQTREL VDRAVNRIKE IITNGVVKAA TGTSPTFNGA TVTVYHQPAP IAQLSPAVSQ KPPFQSGMHY VQDKLFVGLE HAVPTFNVKE KVEGPGCSYL QHIQIETGAK VFLRGKGSGC IEPASGREAF EPMYIYISHP KPEGLAAAKK LCENLLQTVH AEYSRFVNQI NTAVPLPGYT QPSAISSVPP QPPYYPSNGY QSGYPVVPPP QQPVQPPYGV PSIVPPAVSL APGVLPALPT GVPPVPTQYP ITQVQPPAST GQSPMGGPFI PAAPVKTALP AGPQPQPQPQ PPLPSQPQAQ KRRFTEELPD ERESGLLGYQ HGPIHMTNLG TGFSSQNEIE GAGSKPASSS GKERERDRQL MPPPAFPVTG IKTESDERNG SGTLTGSHDY PAKKMKTTEK GFGLVAYAAD SSDEEEEHGG HKNASSFPQG WSLGYQYPSS QPRAKQQMPF WMAP
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