Cytokine-dependent hematopoietic cell linker (CLNK)
Homo sapiens — UniProt Q7Z7G1
Data last refreshed: (UniProt release unknown)
Key facts
Cytokine-dependent hematopoietic cell linker (CLNK) is a protein from Homo sapiens identified by UniProt accession Q7Z7G1, 428 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: Q7Z7G1; gene symbol CLNK.
- Organism: Homo sapiens.
- Length: 428 amino acids.
- Top disease associations (Open Targets): urate measurement, hypothyroidism and rheumatoid arthritis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytokine-dependent hematopoietic cell linker |
|---|---|
| UniProt accession | Q7Z7G1 |
| Gene | CLNK |
| Organism | Homo sapiens |
| Length | 428 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.48
- hypothyroidism · score 0.38
- rheumatoid arthritis · score 0.37
- cognitive function measurement · score 0.35
- Thyroid preparation use measurement · score 0.33
- gout · score 0.29
- chronotype measurement · score 0.29
- autoimmune disease · score 0.27
- autoimmune thyroid disease · score 0.27
- diabetes mellitus · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7G1-F1 | alphafold | PREDICTED | 56.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7G1.
Amino-acid sequence (428 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLNK?
The strongest Open Targets associations for CLNK are urate measurement, hypothyroidism, rheumatoid arthritis, cognitive function measurement and Thyroid preparation use measurement.
How long is the CLNK protein?
The Homo sapiens CLNK protein (UniProt Q7Z7G1) is 428 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7G1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7G1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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