Complexin-4 (CPLX4)
Homo sapiens — UniProt Q7Z7G2
Data last refreshed: (UniProt release unknown)
Key facts
Complexin-4 (CPLX4) is a protein from Homo sapiens identified by UniProt accession Q7Z7G2, 160 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q7Z7G2; gene symbol CPLX4.
- Organism: Homo sapiens.
- Length: 160 amino acids.
- Top disease associations (Open Targets): lean body mass, macula measurement and PR interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Complexin-4 |
|---|---|
| UniProt accession | Q7Z7G2 |
| Gene | CPLX4 |
| Organism | Homo sapiens |
| Length | 160 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.15
- macula measurement · score 0.14
- PR interval · score 0.08
- bone density · score 0.07
- urate measurement · score 0.07
- total blood protein measurement · score 0.06
- cardiac troponin I measurement · score 0.06
- serum albumin measurement · score 0.06
- hemoglobin E-beta-thalassemia syndrome · score 0.06
- Adult-onset autosomal recessive sideroblastic anemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7G2-F1 | alphafold | PREDICTED | 73.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7G2.
Amino-acid sequence (160 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CPLX4?
The strongest Open Targets associations for CPLX4 are lean body mass, macula measurement, PR interval, bone density and urate measurement.
How long is the CPLX4 protein?
The Homo sapiens CPLX4 protein (UniProt Q7Z7G2) is 160 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7G2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7G2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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