Transmembrane emp24 domain-containing protein 4 (TMED4)
Homo sapiens — UniProt Q7Z7H5
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane emp24 domain-containing protein 4 (TMED4) is a protein from Homo sapiens identified by UniProt accession Q7Z7H5, 227 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q7Z7H5; gene symbol TMED4.
- Organism: Homo sapiens.
- Length: 227 amino acids.
- Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, multiple sclerosis and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane emp24 domain-containing protein 4 |
|---|---|
| UniProt accession | Q7Z7H5 |
| Gene | TMED4 |
| Organism | Homo sapiens |
| Length | 227 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.26
- multiple sclerosis · score 0.23
- Alzheimer disease · score 0.23
- neurodegenerative disease · score 0.23
- lysosomal storage disease · score 0.23
- Parkinson disease · score 0.23
- alcohol drinking · score 0.20
- sleep duration · score 0.20
- alcohol consumption measurement · score 0.13
- physical activity · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7H5-F1 | alphafold | PREDICTED | 85.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7H5.
Amino-acid sequence (227 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMED4?
The strongest Open Targets associations for TMED4 are low density lipoprotein cholesterol measurement, multiple sclerosis, Alzheimer disease, neurodegenerative disease and lysosomal storage disease.
How long is the TMED4 protein?
The Homo sapiens TMED4 protein (UniProt Q7Z7H5) is 227 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7H5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7H5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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