Developmental pluripotency-associated protein 2 (DPPA2)
Homo sapiens — UniProt Q7Z7J5
Data last refreshed: (UniProt release unknown)
Key facts
Developmental pluripotency-associated protein 2 (DPPA2) is a protein from Homo sapiens identified by UniProt accession Q7Z7J5, 298 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q7Z7J5; gene symbol DPPA2.
- Organism: Homo sapiens.
- Length: 298 amino acids.
- Top disease associations (Open Targets): primary ovarian insufficiency, adolescent idiopathic scoliosis and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Developmental pluripotency-associated protein 2 |
|---|---|
| UniProt accession | Q7Z7J5 |
| Gene | DPPA2 |
| Organism | Homo sapiens |
| Length | 298 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.27
- adolescent idiopathic scoliosis · score 0.14
- cancer · score 0.03
- Down syndrome · score 0.03
- non-small cell lung carcinoma · score 0.02
- gonorrhea · score 0.02
- neoplasm · score 0.02
- Ataxia-telangiectasia · score 0.01
- esophageal squamous cell carcinoma · score 0.01
- infection · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7J5-F1 | alphafold | PREDICTED | 68.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7J5.
Amino-acid sequence (298 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DPPA2?
The strongest Open Targets associations for DPPA2 are primary ovarian insufficiency, adolescent idiopathic scoliosis, cancer, Down syndrome and non-small cell lung carcinoma.
How long is the DPPA2 protein?
The Homo sapiens DPPA2 protein (UniProt Q7Z7J5) is 298 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7J5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7J5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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