Schlafen family member 11 (SLFN11)
Homo sapiens — UniProt Q7Z7L1
Data last refreshed: (UniProt release unknown)
Key facts
Schlafen family member 11 (SLFN11) is a protein from Homo sapiens identified by UniProt accession Q7Z7L1, 901 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.
- UniProt accession: Q7Z7L1; gene symbol SLFN11.
- Organism: Homo sapiens.
- Length: 901 amino acids.
- Top disease associations (Open Targets): cancer, neoplasm and inflammatory bowel disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Schlafen family member 11 |
|---|---|
| UniProt accession | Q7Z7L1 |
| Gene | SLFN11 |
| Organism | Homo sapiens |
| Length | 901 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (104)
Diseases linked to this target (Open Targets).
- cancer · score 0.11
- neoplasm · score 0.11
- inflammatory bowel disease · score 0.09
- small cell lung carcinoma · score 0.09
- blood protein measurement · score 0.09
- esophageal squamous cell carcinoma · score 0.09
- hepatocellular carcinoma · score 0.08
- breast cancer · score 0.08
- nonpapillary renal cell carcinoma · score 0.08
- glioblastoma multiforme · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z7L1-F1 | alphafold | PREDICTED | 86.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z7L1.
Amino-acid sequence (901 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLFN11?
The strongest Open Targets associations for SLFN11 are cancer, neoplasm, inflammatory bowel disease, small cell lung carcinoma and blood protein measurement.
How long is the SLFN11 protein?
The Homo sapiens SLFN11 protein (UniProt Q7Z7L1) is 901 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z7L1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z7L1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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