About Deleted in azoospermia protein 4
Deleted in azoospermia protein 4 (DAZ4) is a protein
from Homo sapiens identified by UniProt accession
Q86SG3, 579 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (132)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 1 · score 0.08
- spermatogenic failure 48 · score 0.07
- primary ovarian insufficiency · score 0.07
- spermatogenic failure 25 · score 0.07
- spermatogenic failure 22 · score 0.07
- spermatogenic failures 50 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q86SG3.
Amino-acid sequence (579 residues)
MSAANPETPN STISREASTQ SSSAAASQGW VLPEGKIVPN TVFVGGIDAR MDETEIGSCF GRYGSVKEVK IITNRTGVSK GYGFVSFVND VDVQKIVGSQ IHFHGKKLKL GPAIRKQKLC ARHVQPRPLV VNPPPPPQFQ NVWRNPNTET YLQPQITPNP VTQHVQSAAN PETPNSTISR EASTQSSSAA ASQGWVLPEG KIVPNTVFVG GIDARMDETE IGSCFGRYGS VKEVKIITNR TGVSKGYGFV SFVNDVDVQK IVGSQIHFHG KKLKLGPAIR KQKLCARHVQ PRPLVVNPPP PPQFQNVWRN PNTETYLQPQ ITPNPVTQHV QAYSAYPHSP GQVITGCQLL VYNYQEYPTY PDSAFQVTTG YQLPVYNYQP FPAYPRSPFQ VTAGYQLPVY NYQAFPAYPN SPFQVATGYQ FPVYNYQPFP AYPSSPFQVT AGYQLPVYNY QAFPAYPNSP FQVATGYQFP VYNYQAFPAY PNSPVQVTTG YQLPVYNYQA FPAYPSSPFQ VTTGYQLPVY NYQAFPAYPN SAVQVTTGYQ FHVYNYQMPP QCPVGEQRRN LWTEAYKWWY LVCLIQRRD
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