Serine/threonine-protein kinase Nek8 (NEK8)
Homo sapiens — UniProt Q86SG6
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase Nek8 (NEK8) is a protein from Homo sapiens identified by UniProt accession Q86SG6, 692 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.
- UniProt accession: Q86SG6; gene symbol NEK8.
- Organism: Homo sapiens.
- Length: 692 amino acids.
- Top disease associations (Open Targets): renal-hepatic-pancreatic dysplasia, nephronophthisis and Nephronophthisis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase Nek8 |
|---|---|
| UniProt accession | Q86SG6 |
| Gene | NEK8 |
| Organism | Homo sapiens |
| Length | 692 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (199)
Diseases linked to this target (Open Targets).
- renal-hepatic-pancreatic dysplasia · score 0.76
- nephronophthisis · score 0.72
- Nephronophthisis · score 0.47
- Autosomal dominant polycystic kidney disease · score 0.38
- Polycystic Kidney Disease · score 0.37
- Infantile nephronophthisis · score 0.37
- neuroinflammatory disorder · score 0.34
- pancreatic neoplasm · score 0.26
- neurodegenerative disease · score 0.22
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86SG6-F1 | alphafold | PREDICTED | 84.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86SG6.
Amino-acid sequence (692 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NEK8?
The strongest Open Targets associations for NEK8 are renal-hepatic-pancreatic dysplasia, nephronophthisis, Nephronophthisis, Autosomal dominant polycystic kidney disease and Polycystic Kidney Disease.
How long is the NEK8 protein?
The Homo sapiens NEK8 protein (UniProt Q86SG6) is 692 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86SG6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86SG6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.