Adhesion G protein-coupled receptor A1 (ADGRA1)
Homo sapiens — UniProt Q86SQ6
Data last refreshed: (UniProt release unknown)
Key facts
Adhesion G protein-coupled receptor A1 (ADGRA1) is a protein from Homo sapiens identified by UniProt accession Q86SQ6, 560 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q86SQ6; gene symbol ADGRA1.
- Organism: Homo sapiens.
- Length: 560 amino acids.
- Target class: GPCR.
- Top disease associations (Open Targets): gastroesophageal reflux disease, MODY and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Adhesion G protein-coupled receptor A1 |
|---|---|
| UniProt accession | Q86SQ6 |
| Gene | ADGRA1 |
| Organism | Homo sapiens |
| Length | 560 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | GPCR (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- gastroesophageal reflux disease · score 0.30
- MODY · score 0.08
- self reported educational attainment · score 0.07
- diabetes mellitus, transient neonatal, 2 · score 0.05
- multisite chronic pain · score 0.03
- urinary bladder carcinoma · score 0.03
- medulloblastoma · score 0.02
- visual perception measurement · score 0.02
- anxiety · score 0.02
- Ataxia-telangiectasia · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86SQ6-F1 | alphafold | PREDICTED | 63.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86SQ6.
Amino-acid sequence (560 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADGRA1?
The strongest Open Targets associations for ADGRA1 are gastroesophageal reflux disease, MODY, self reported educational attainment, diabetes mellitus, transient neonatal, 2 and multisite chronic pain.
How long is the ADGRA1 protein?
The Homo sapiens ADGRA1 protein (UniProt Q86SQ6) is 560 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86SQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86SQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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