Pre-mRNA-processing factor 39 (PRPF39)
Homo sapiens — UniProt Q86UA1
Data last refreshed: (UniProt release unknown)
Key facts
Pre-mRNA-processing factor 39 (PRPF39) is a protein from Homo sapiens identified by UniProt accession Q86UA1, 669 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q86UA1; gene symbol PRPF39.
- Organism: Homo sapiens.
- Length: 669 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, genetic disorder and sphingomyelin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pre-mRNA-processing factor 39 |
|---|---|
| UniProt accession | Q86UA1 |
| Gene | PRPF39 |
| Organism | Homo sapiens |
| Length | 669 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.12
- sphingomyelin measurement · score 0.06
- hemoglobin D disease · score 0.05
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
- hemolytic anemia due to glutathione reductase deficiency · score 0.05
- dominant beta-thalassemia · score 0.04
- hemoglobin E-beta-thalassemia syndrome · score 0.04
- hemoglobin E disease · score 0.04
- delta-beta-thalassemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86UA1-F1 | alphafold | PREDICTED | 81.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86UA1.
Amino-acid sequence (669 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRPF39?
The strongest Open Targets associations for PRPF39 are neurodegenerative disease, genetic disorder, sphingomyelin measurement, hemoglobin D disease and hereditary persistence of fetal hemoglobin-sickle cell disease syndrome.
How long is the PRPF39 protein?
The Homo sapiens PRPF39 protein (UniProt Q86UA1) is 669 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86UA1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86UA1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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