B-cell CLL/lymphoma 9-like protein (BCL9L)
Homo sapiens — UniProt Q86UU0
Data last refreshed: (UniProt release unknown)
Key facts
B-cell CLL/lymphoma 9-like protein (BCL9L) is a protein from Homo sapiens identified by UniProt accession Q86UU0, 1499 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.
- UniProt accession: Q86UU0; gene symbol BCL9L.
- Organism: Homo sapiens.
- Length: 1499 amino acids.
- Top disease associations (Open Targets): colorectal adenocarcinoma, Endometrial Endometrioid Adenocarcinoma and gastric carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | B-cell CLL/lymphoma 9-like protein |
|---|---|
| UniProt accession | Q86UU0 |
| Gene | BCL9L |
| Organism | Homo sapiens |
| Length | 1499 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (160)
Diseases linked to this target (Open Targets).
- colorectal adenocarcinoma · score 0.56
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- gastric carcinoma · score 0.37
- nodular melanoma · score 0.37
- cecum adenocarcinoma · score 0.37
- gastric intestinal type adenocarcinoma · score 0.37
- lymphoid neoplasm · score 0.37
- cutaneous melanoma · score 0.37
- colon adenocarcinoma · score 0.37
- skin squamous cell carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86UU0-F1 | alphafold | PREDICTED | 42.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86UU0.
Amino-acid sequence (1499 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BCL9L?
The strongest Open Targets associations for BCL9L are colorectal adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, gastric carcinoma, nodular melanoma and cecum adenocarcinoma.
How long is the BCL9L protein?
The Homo sapiens BCL9L protein (UniProt Q86UU0) is 1499 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86UU0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86UU0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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