Probable E3 ubiquitin-protein ligase DTX2 (DTX2)
Homo sapiens — UniProt Q86UW9
Data last refreshed: (UniProt release unknown)
Key facts
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) is a protein from Homo sapiens identified by UniProt accession Q86UW9, 622 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q86UW9; gene symbol DTX2.
- Organism: Homo sapiens.
- Length: 622 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, head and neck squamous cell carcinoma and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable E3 ubiquitin-protein ligase DTX2 |
|---|---|
| UniProt accession | Q86UW9 |
| Gene | DTX2 |
| Organism | Homo sapiens |
| Length | 622 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- head and neck squamous cell carcinoma · score 0.21
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- diffuse large B-cell lymphoma · score 0.14
- genetic disorder · score 0.12
- glioblastoma multiforme · score 0.11
- triglyceride measurement · score 0.05
- neoplasm · score 0.05
- metabolite measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86UW9-F1 | alphafold | PREDICTED | 71.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86UW9.
Amino-acid sequence (622 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DTX2?
The strongest Open Targets associations for DTX2 are neurodegenerative disease, head and neck squamous cell carcinoma, ovarian cancer, breast adenocarcinoma and diffuse large B-cell lymphoma.
How long is the DTX2 protein?
The Homo sapiens DTX2 protein (UniProt Q86UW9) is 622 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86UW9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86UW9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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