5'-nucleotidase domain-containing protein 3 (NT5DC3)
Homo sapiens — UniProt Q86UY8
Data last refreshed: (UniProt release unknown)
Key facts
5'-nucleotidase domain-containing protein 3 (NT5DC3) is a protein from Homo sapiens identified by UniProt accession Q86UY8, 548 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q86UY8; gene symbol NT5DC3.
- Organism: Homo sapiens.
- Length: 548 amino acids.
- Top disease associations (Open Targets): central corneal thickness, IGF-1 measurement and von Willebrand factor measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 5'-nucleotidase domain-containing protein 3 |
|---|---|
| UniProt accession | Q86UY8 |
| Gene | NT5DC3 |
| Organism | Homo sapiens |
| Length | 548 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- central corneal thickness · score 0.29
- IGF-1 measurement · score 0.26
- von Willebrand factor measurement · score 0.18
- factor VIII measurement · score 0.15
- venous thromboembolism · score 0.10
- cor pulmonale · score 0.09
- pulmonary embolism · score 0.08
- adolescent idiopathic scoliosis · score 0.08
- type 2 diabetes mellitus · score 0.07
- lymphatic system disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86UY8-F1 | alphafold | PREDICTED | 85.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86UY8.
Amino-acid sequence (548 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NT5DC3?
The strongest Open Targets associations for NT5DC3 are central corneal thickness, IGF-1 measurement, von Willebrand factor measurement, factor VIII measurement and venous thromboembolism.
How long is the NT5DC3 protein?
The Homo sapiens NT5DC3 protein (UniProt Q86UY8) is 548 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86UY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86UY8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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