Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42)
Homo sapiens — UniProt Q86VD7
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) is a protein from Homo sapiens identified by UniProt accession Q86VD7, 318 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q86VD7; gene symbol SLC25A42.
- Organism: Homo sapiens.
- Length: 318 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): metabolic crises, recurrent, with variable encephalomyopathic features and neurologic regression, Mitochondrial myopathy and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial coenzyme A transporter SLC25A42 |
|---|---|
| UniProt accession | Q86VD7 |
| Gene | SLC25A42 |
| Organism | Homo sapiens |
| Length | 318 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- metabolic crises, recurrent, with variable encephalomyopathic features and neurologic regression · score 0.72
- Mitochondrial myopathy · score 0.53
- neurodegenerative disease · score 0.43
- genetic disorder · score 0.34
- inborn mitochondrial myopathy · score 0.27
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.05
- partial chromosome Y deletion · score 0.05
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.05
- spermatogenic failure 61 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86VD7-F1 | alphafold | PREDICTED | 90.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86VD7.
Amino-acid sequence (318 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC25A42?
The strongest Open Targets associations for SLC25A42 are metabolic crises, recurrent, with variable encephalomyopathic features and neurologic regression, Mitochondrial myopathy, neurodegenerative disease, genetic disorder and inborn mitochondrial myopathy.
How long is the SLC25A42 protein?
The Homo sapiens SLC25A42 protein (UniProt Q86VD7) is 318 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86VD7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86VD7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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