Thioredoxin reductase 3 (TXNRD3)
Homo sapiens — UniProt Q86VQ6
Data last refreshed: (UniProt release unknown)
Key facts
Thioredoxin reductase 3 (TXNRD3) is a protein from Homo sapiens identified by UniProt accession Q86VQ6, 643 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.
- UniProt accession: Q86VQ6; gene symbol TXNRD3.
- Organism: Homo sapiens.
- Length: 643 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, metabolite measurement and azoospermia.
Target properties
| Protein name | Thioredoxin reductase 3 |
|---|---|
| UniProt accession | Q86VQ6 |
| Gene | TXNRD3 |
| Organism | Homo sapiens |
| Length | 643 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (109)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- metabolite measurement · score 0.12
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- blood protein measurement · score 0.08
- PHF-tau measurement · score 0.07
- mean platelet volume · score 0.07
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 7 · score 0.07
- spermatogenic failure 56 · score 0.06
3D Structure
Predicted structure for Q86VQ6 is available from the AlphaFold Protein Structure Database.
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86VQ6.
Amino-acid sequence (643 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TXNRD3?
The strongest Open Targets associations for TXNRD3 are neurodegenerative disease, metabolite measurement, azoospermia, male infertility with teratozoospermia due to single gene mutation and blood protein measurement.
How long is the TXNRD3 protein?
The Homo sapiens TXNRD3 protein (UniProt Q86VQ6) is 643 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86VQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86VQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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