Rotatin (RTTN)

Homo sapiens — UniProt Q86VV8

Gene: RTTNHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Rotatin (RTTN) is a protein from Homo sapiens identified by UniProt accession Q86VV8, 2226 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

UniProt accession: Q86VV8; gene symbol RTTN.
Organism: Homo sapiens.
Length: 2226 amino acids.
Top disease associations (Open Targets): microcephalic primordial dwarfism due to RTTN deficiency, bilateral generalized polymicrogyria and bilateral polymicrogyria.
3D structure: AlphaFold model available.

Target properties

Protein name	Rotatin
UniProt accession	Q86VV8
Gene	RTTN
Organism	Homo sapiens
Length	2226 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

microcephalic primordial dwarfism due to RTTN deficiency · score 0.76
bilateral generalized polymicrogyria · score 0.68
bilateral polymicrogyria · score 0.54
mean corpuscular volume · score 0.49
Primary microcephaly · score 0.47
Microcephaly · score 0.41
mean reticulocyte volume · score 0.41
mean platelet volume · score 0.41
Intellectual disability · score 0.37
autosomal recessive primary microcephaly · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VV8-F1	alphafold	PREDICTED	77.14	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86VV8.

Amino-acid sequence (2226 residues)

MVLAGLIRKL GHQLAEIRER ALKSILCKIE HNLICYADLI QERQLFLHLL EWFNFPSVPM KEEVLNLLSR LVKYPPAVQH LVDVGAVEFL SKLRSNVEPN LQAEIDGILD GLFLLPSEVP ALSSASYQTN QTELSKNPEI LTGYFPQDKS NFQQMEVPPR PVVNQTVKCL KFSTFPWLPL TTTDRHVLSS NESSLRSSNH TLIWNTCELL KDVIMQDFPA EIFLQRPKIV QSLLSLLKLA FGDGKHRLAL QSVSCLQQLC MYLRNRLNFH RDPGFFSNKH DTVSQNSSLS YCHEARGTHH SQNPSPGSSS PRPSVVGRTG QRPRGDGQDW DAASSSGSSS HAHVNSRISV HSPLDMGHID LPELETEDTL ELQFQQLSLP QFCVSILESA VPLLRTGSRQ VIIRVLELLT EDMTLIGEAI STDIWDDSSL FGIDMKEKLL LVLGALGETM CYHKSSISLE QPEVMLVHHR MAFISISLFA VRLLQTLLPV EKASEFLSEP MSTALFLLSL DMPISLEYPN IHEAVVAYLE QLNSENYSIY KRTAEAVYSI ECTCNFLSDI GKEGEKNLLE LVELADQALR SFSYHQHFPL IKEIISICSK IWKSAQASPL LQGESQKVLL HMLSHPLPRV KAETYHCCLE ITKECLGVHN VTKPVSSLCN GIHFLLHPKV LYEISVFGIQ EPESEVNTAA KAILLYLLQG RLMMTALTWN KFIESLCPVI PILQGYADTE DPLGNCILLL SKASSDTEEM LPCTTRLKSM LRLLLVKKPS VRSLALKLLA FHLTSEEGAD TKRPLIDARV LSRVTDLFIG KKPIELRLDD RRELVIKLET VEKVYEIFTS DDVDLVLRKS AAEQLAVIMQ DIKMHAVVKK LCLIDKIIEY LNECVSQDGK VVECLVQPCL TLLRKVLCGD PVMRVSLSQQ SSLLTVLFRV SLIFHEDCSV VTEVGALFCL LLFDEVSRMD MWSVNPSNKP SLPSVFSLPV SVFRRYHLPV HVIGHHAVSP YSIVLPLSAD CLALKPVSDM LRIAWNLSWY HGSDNLLKQM NSETKTQEIL DALKLSTEDI LTLKITHMAS GLQDCLHSIV QAATHREVRA AVTRMSFYLL NDRLSLKGCP GPCGVTLKSL AWHTALNRFL QVLPACTEDE KLLIDIIHFL NKLIKEQRKN SSLELLNWIL ELLLRHSANP LLDLLVLTES QAREETDDIR TAVRQQLQKE LIALFDTLLL NFMEVTDRKC SELLYVFQTQ LALKLLQCLK VTDAPHFYGL PSLERTLRGM ANLTAFPGWS SHSPLTKPLD ICVKYLSGLL EVITSFYVER GGNAMSFMGK GVTKSTILCL LHLSHEMMAQ AGSLEWMSLW FLPLGSHSEE HIPTQQGLAW LIPLWVDRDP EVRFTSLGLG SALTTLETGC VALANSCQNI SGGLWGTVVN ILLDQSECSM VRREAAFILQ NLLVIPMPTE IIKDYTWQGP CVHDEDSGLS LIGKPALQAL LYHCHFYEHL NQMVKHCYLG RCMFDLNFSA FDRNSESNDL NGLDDSFKFW RAPSRTSQDR DPSSLSTSET TVAPSLGSTE FQPLVQSTTL LPEASHDQFV AQGHQESTSP RPPHDSSLSA PLPKLCVFVT PSLLSAMCSL LDNLLTIAPR DTAKAFRQAH LIELLCSIAD ATLIQTCVQE LRALLPSSPP AEHTQAQVSF LLEYLSSLSR LLQSCLLVEP DLVIQDELVK PLITNIIGIL TICTKDVLDK ELISAFYHTW THLFNLLAML LRKAGAITLP FVTVALAKHW TAAIDMFCTC AGLSATCPAL YTASLQFLSV LLTEEAKGHL QAKSKTHLCC SPTVASLLDD SQENQKSLEQ LSDVILQCYE GKSSKDILKR VAANALMSLL AVSRRAQKHA LKANLIDNCM EQMKHINAQL NLDSLRPGKA ALKKKEDGVI KELSIAMQLL RNCLYQNEEC KEAALEAHLV PVLHSLWPWI LMDDSLMQIS LQLLCVYTAN FPNGCSSLCW SSCGQHPVQA THRGAVSNSL MLCILKLASQ MPLENTTVQQ MVFMLLSNLA LSHDCKGVIQ KSNFLQNFLS LALPKGGNKH LSNLTILWLK LLLNISSGED GQQMILRLDG CLDLLTEMSK YKHKSSPLLP LLIFHNVCFS PANKPKILAN EKVITVLAAC LESENQNAQR IGAAALWALI YNYQKAKTAL KSPSVKRRVD EAYSLAKKTF PNSEANPLNA YYLKCLENLV QLLNSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with RTTN?

The strongest Open Targets associations for RTTN are microcephalic primordial dwarfism due to RTTN deficiency, bilateral generalized polymicrogyria, bilateral polymicrogyria, mean corpuscular volume and Primary microcephaly.

How long is the RTTN protein?

The Homo sapiens RTTN protein (UniProt Q86VV8) is 2226 amino acids long.

Browse: Targets: R · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q86VV8 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q86VV8 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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