About HEAT repeat-containing protein 5A
HEAT repeat-containing protein 5A (HEATR5A) is a protein
from Homo sapiens identified by UniProt accession
Q86XA9, 2040 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (14)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.27
- birth weight · score 0.25
- cystatin C measurement · score 0.19
- creatinine measurement · score 0.17
- diet measurement · score 0.17
- low density lipoprotein cholesterol measurement · score 0.12
- Skull Fractures · score 0.04
- axial length measurement · score 0.02
- inflammatory bowel disease · score 0.02
- chronic kidney disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q86XA9.
Amino-acid sequence (2040 residues)
MELAHSLLLN EEAYNQLGEV QKAEFIFEWL RYLEKLLLAT SRNDVREKQK TLVEQLLSLL NSSPGPPTRK LLAKNLAILY SIGDTFSVHE AIDKCNDLIR SKDDSPSYLP TKLAAVVCLG SLYKKLGRIL GNTFTDTVGN ILKAMKSAES QGRYEIMLSL QNILNGLGAA AAPCHRDVYK AARSCLTDRS MAVRCAAAKN EAIFMWSTDL DSVATLCFKS FEGSNYDVRI SVSKLLGIIL AKAVISKHPG TAASRQSIRR VSLEEVLELL GTGFLRGSSG FLRASGDMLK GTSSVSRDVR VGVTQAYVVF VSTLGGAWLE KNFAAFFSHI LSLASPSHPK ATQTQIDAVC CRRCVSFILR TTIGGLLGEK AQLAAVKDIC QAIWKLKKVM DAVMSDGNLE TRLGSTDVAA SQHMLVCALQ ELGNLIHNLG TTAAPLLQDS STGLLDSILS VILHPSISVR LAAAWCLHCI AVALPSYLTP LLDRCLERLT GHKSSPEAVT GFSFAVAALL GAVKHCPLGI PHGKGKIIMT LAEDLLCSAA QNSRLSAQRT QAGWLLISAL MTLGPAVVSH HLARVLLLWK CVFPASPKDL ETEKSRGDSF TWQVTLEGRA GALCAIKSFV SHCGDLLTEE VTQRLLPPLP CAVDLLTQLS SILKMYGSPL KTPSVVYRQR LYELLILLPP ETYEGNLCAI LRELAADLTA PDIQVAASTF LLPPLCHQDD LLILSPFLQE TDHRFIEEQL LLGNGVACGS LEYDPYSIYE KDVEGDSVPK PLPPALSVIS SASKLFGVVC AHVGETQRLL ILEQLLDSIK HTKGARQQVV QLHVVSSVSS FLKYVAGSKG CLGPEEMKRF ALTLVMGALE SPNPLLRCAA AESWARLAQV VDDGAFTAGL AQVSFDKLKS ARDVVTRTGH SLALGSLHRY LGGISSSQHL NSCIGILYTL AQDSTSPDVQ TWALHSLSLI IDSAGPLYYV HVEPTLSLII MLLLNVPPTH AEVHQSLGRC LNALITTLGP ELQGNSTSIS TLRTSCLLGC AVMQDNPDCL VQAQAISCLQ QLHMFAPRHV NLSSLVSCLC VNLCSPYLLL RRAVLACLRQ LVQREAAEVS EHAVMLAKDS REELTPDANI REVGLEGALL ILLDKETDER LCHDIKETLN YMLTSMAVEK LSLWLKLCKD VLAASADFTA VTCVDTMQEE EGDKGDDASV LTTRRDEKSH PFTNPRWATR VFAAECVCRI INQCENANSA HFDIALAQEM KKRDSRNDFL VLHLADLIRM AFMAATDHSD QLRLSGLEML LVVIRRFATV PEPEFPGHVI LEQYQANVGA ALRPAFTSET PPDVTAKACQ VCSAWIASGV VSDLNDLRRV HQLLVSSLTK IQAGKEALSH LYNESASTME ILAVLKAWAE VYIIAVQRHK NHRQPLKTTT CLEDGIRNGS CSSDGLLDLV YADLGTLSRL WLAALQDFAL LTLPSEFASQ LPAEGGAFYT AETSENAKLH YYNSWALILH ATALWLTSTG FVVADPDEGA SNLSRPVTPT SMCQGSSSGA TIKSPEDVYT DRFHLILGIS VEFLCSLRSD ATMESITACL HALQALLDVP WPRSKIGSDQ DLGIELLNVL HRVILTRESP SIQLASLEVV RQIICAAQEH VKEKRRSAEV DDGAAEKETL PEFGEGKDTG GLVPGKSLVF ATLELCVCIL VRQLPELNPK LTGSPGVKAT KPQILLEDGS RLVSAALVIL SELPAVCSPE GSISILPTIL YLTIGVLRET AVKLPGGQLS STVAASLQAL KGILSSPMAR AEKSRTAWTD LLRSALTTIL DCWDPVDETH QELDEVSLLT AITVFILSTS PEVTTIPCLQ KRCIDKFKAT LEIKDPVVQI KTYQLLHSIF QYPNPAVSYP YIYSLASCIM EKLQEIDKRK PENTAELEIF QEGIKVLETL VTVAEEHHRA QLVACLLPIL ISFLLDENSL GSATSIMRNL HDFALQNLMQ IGPQYSSVFK SLVASSPALK ARLEAAIKGN QESVKVKIPT SKYTKSPGKN SSIQLKTSFL
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