About Dynein regulatory complex subunit 11
Dynein regulatory complex subunit 11 (DRC11) is a protein
from Homo sapiens identified by UniProt accession
Q86XH1, 822 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (91)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.32
- polycystic ovary syndrome · score 0.29
- inflammatory bowel disease · score 0.29
- neuroimaging measurement · score 0.20
- cortical thickness · score 0.20
- brain measurement · score 0.19
- cortical surface area measurement · score 0.18
- heel bone mineral density · score 0.17
- serum metabolite measurement · score 0.12
- neutrophil count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q86XH1.
Amino-acid sequence (822 residues)
MSNAMYNKMW HQTQEALGAL LDKEPQKMIE PQRNQVFIFQ TLATFYVKYV QIFRNLENVY DQFVHPQKRI LIRKVLDGVM GRILELKNEM VELELTEFHY FDDILQDLKL APQQLDIPIP KYFLKEKLEV IKGREKILAQ ILADSGIDTS DMKYPVKSIP FDEAVKLIQI AERARQGRLR ALFMKQIYLQ EYRAKQSKML GKKVTDTWAA ALRIQKVWRR FHQRKETEKL REEEMIFLGM NPPPLFNEVS ATVIQAEKVD RLRNEVQIKH EEDYREALVT IKNDLKLIEG VDIKENLQDQ IRHWFIECRN LTGTFPDYPD VEEGGSAIIF SDKTIQQVIE DIIANQEEEE KNKKKKKKKE KQPKKAKKQK KGTKEKNKEE DEKWKMSPSL FLPAMKEGCN AYKEIWMKKD ESWNFSQDYD PELIKEEKRK ELQSEIRIQV DELMRQELKN LKLAVDRERE RPVKAGKKKD KKGKKGKKKE KKAKKDKDLT ADRTIESLYK ELVEEGLLIQ ALKVNLSDYI GEYSYLGTTL RQVSIEPMPS LLDVRQLITL YGIWPLGSAA VHEKAPLVKS LLLAGPSGVG KKMLVHAICT ETGANLFNLS SSNIAGKYPG KNGLQMMLHA VFKVARQLQP SVVWIEDTEK TFYKKVPNAE KMNEPKRLKK HLPQILKLLK PDDRILIVGT TRRPFDAELQ SFCKVYQKII LVPRPDYASR YVLWKQIIER NGGVLTSALN VSCLAKVTDG FTQGHIVEVV KGVLTDQRIR RQIHKPLTAV EFITAITSMN PVYKEEEESF KNWYAKTPLG KKRALAITGG STEKAKDKGK RK
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