Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)

About Protein phosphatase 1 regulatory subunit 3B

Protein phosphatase 1 regulatory subunit 3B (PPP1R3B) is a protein from Homo sapiens identified by UniProt accession Q86XI6, 285 residues long. MolForge cross-references it against 0 known binders and 198 disease associations.

Target properties

Protein name	Protein phosphatase 1 regulatory subunit 3B
UniProt accession	Q86XI6
Gene	PPP1R3B
Organism	Homo sapiens
Length	285 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (198)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
reticulocyte count · score 0.46
high density lipoprotein cholesterol measurement · score 0.46
alcohol drinking · score 0.44
low density lipoprotein cholesterol measurement · score 0.43
total cholesterol measurement · score 0.42
C-reactive protein measurement · score 0.42
diastolic blood pressure · score 0.42
triglyceride measurement · score 0.42
heel bone mineral density · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86XI6-F1	alphafold	PREDICTED	70.51	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86XI6.

Amino-acid sequence (285 residues)

MMAVDIEYRY NCMAPSLRQE RFAFKISPKP SKPLRPCIQL SSKNEASGMV APAVQEKKVK KRVSFADNQG LALTMVKVFS EFDDPLDMPF NITELLDNIV SLTTAESESF VLDFSQPSAD YLDFRNRLQA DHVCLENCVL KDKAIAGTVK VQNLAFEKTV KIRMTFDTWK SYTDFPCQYV KDTYAGSDRD TFSFDISLPE KIQSYERMEF AVYYECNGQT YWDSNRGKNY RIIRAELKST QGMTKPHSGP DLGISFDQFG SPRCSYGLFP EWPSYLGYEK LGPYY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards