Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)
Homo sapiens — UniProt Q86XI6
Data last refreshed: (UniProt release unknown)
Key facts
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B) is a protein from Homo sapiens identified by UniProt accession Q86XI6, 285 residues long. MolForge cross-references it against 0 known binders and 198 disease associations.
- UniProt accession: Q86XI6; gene symbol PPP1R3B.
- Organism: Homo sapiens.
- Length: 285 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, reticulocyte count and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 3B |
|---|---|
| UniProt accession | Q86XI6 |
| Gene | PPP1R3B |
| Organism | Homo sapiens |
| Length | 285 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (198)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- reticulocyte count · score 0.46
- high density lipoprotein cholesterol measurement · score 0.46
- alcohol drinking · score 0.44
- low density lipoprotein cholesterol measurement · score 0.43
- total cholesterol measurement · score 0.42
- C-reactive protein measurement · score 0.42
- diastolic blood pressure · score 0.42
- triglyceride measurement · score 0.42
- heel bone mineral density · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86XI6-F1 | alphafold | PREDICTED | 70.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86XI6.
Amino-acid sequence (285 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPP1R3B?
The strongest Open Targets associations for PPP1R3B are neurodegenerative disease, reticulocyte count, high density lipoprotein cholesterol measurement, alcohol drinking and low density lipoprotein cholesterol measurement.
How long is the PPP1R3B protein?
The Homo sapiens PPP1R3B protein (UniProt Q86XI6) is 285 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86XI6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86XI6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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