E3 ubiquitin-protein ligase MARCHF9 (MARCHF9)

About E3 ubiquitin-protein ligase MARCHF9

E3 ubiquitin-protein ligase MARCHF9 (MARCHF9) is a protein from Homo sapiens identified by UniProt accession Q86YJ5, 346 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase MARCHF9
UniProt accession	Q86YJ5
Gene	MARCHF9
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

platelet count · score 0.07
mean corpuscular volume · score 0.06
alkaline phosphatase measurement · score 0.05
body height · score 0.04
calcium measurement · score 0.04
IGF-1 measurement · score 0.03
cholesterol-ester transfer protein deficiency · score 0.03
hypertriglyceridemia 2 · score 0.03
multiple sclerosis · score 0.03
aspartate aminotransferase measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YJ5-F1	alphafold	PREDICTED	64.59	—

Amino-acid sequence (346 residues)

MLKSRLRMFL NELKLLVLTG GGRPRAEPQP RGGRGGGCGW APFAGCSTRD GDGDEEEYYG SEPRARGLAG DKEPRAGPLP PPAPPLPPPG ALDALSLSSS LDSGLRTPQC RICFQGPEQG ELLSPCRCDG SVRCTHQPCL IRWISERGSW SCELCYFKYQ VLAISTKNPL QWQAISLTVI EKVQIAAIVL GSLFLVASIS WLIWSSLSPS AKWQRQDLLF QICYGMYGFM DVVCIGLIIH EGSSVYRIFK RWQAVNQQWK VLNYDKTKDI GGDAGGGTAG KSGPRNSRTG PTSGATSRPP AAQRMRTLLP QRCGYTILHL LGQLRPPDAR SSSHSGREVV MRVTTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards