E3 ubiquitin-protein ligase MARCHF9 (MARCHF9)
Homo sapiens — UniProt Q86YJ5
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase MARCHF9 (MARCHF9) is a protein from Homo sapiens identified by UniProt accession Q86YJ5, 346 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q86YJ5; gene symbol MARCHF9.
- Organism: Homo sapiens.
- Length: 346 amino acids.
- Top disease associations (Open Targets): platelet count, mean corpuscular volume and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase MARCHF9 |
|---|---|
| UniProt accession | Q86YJ5 |
| Gene | MARCHF9 |
| Organism | Homo sapiens |
| Length | 346 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- platelet count · score 0.07
- mean corpuscular volume · score 0.06
- alkaline phosphatase measurement · score 0.05
- body height · score 0.04
- calcium measurement · score 0.04
- IGF-1 measurement · score 0.03
- cholesterol-ester transfer protein deficiency · score 0.03
- hypertriglyceridemia 2 · score 0.03
- multiple sclerosis · score 0.03
- aspartate aminotransferase measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86YJ5-F1 | alphafold | PREDICTED | 64.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86YJ5.
Amino-acid sequence (346 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MARCHF9?
The strongest Open Targets associations for MARCHF9 are platelet count, mean corpuscular volume, alkaline phosphatase measurement, body height and calcium measurement.
How long is the MARCHF9 protein?
The Homo sapiens MARCHF9 protein (UniProt Q86YJ5) is 346 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86YJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86YJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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