Junctional adhesion molecule-like (JAML)
Homo sapiens — UniProt Q86YT9
Data last refreshed: (UniProt release unknown)
Key facts
Junctional adhesion molecule-like (JAML) is a protein from Homo sapiens identified by UniProt accession Q86YT9, 394 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.
- UniProt accession: Q86YT9; gene symbol JAML.
- Organism: Homo sapiens.
- Length: 394 amino acids.
- Top disease associations (Open Targets): neutrophil count, leukocyte count and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Junctional adhesion molecule-like |
|---|---|
| UniProt accession | Q86YT9 |
| Gene | JAML |
| Organism | Homo sapiens |
| Length | 394 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (76)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.59
- leukocyte count · score 0.58
- monocyte count · score 0.46
- myeloid white cell count · score 0.42
- lymphocyte count · score 0.39
- sum of basophil and neutrophil counts · score 0.35
- lymphocyte percentage of leukocytes · score 0.32
- neutrophil percentage of leukocytes · score 0.32
- granulocyte count · score 0.32
- sum of neutrophil and eosinophil counts · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86YT9-F1 | alphafold | PREDICTED | 73.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86YT9.
Amino-acid sequence (394 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with JAML?
The strongest Open Targets associations for JAML are neutrophil count, leukocyte count, monocyte count, myeloid white cell count and lymphocyte count.
How long is the JAML protein?
The Homo sapiens JAML protein (UniProt Q86YT9) is 394 amino acids long.
Browse: Targets: J · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86YT9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86YT9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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