Beta-klotho (KLB)
Homo sapiens — UniProt Q86Z14
Data last refreshed: (UniProt release unknown)
Key facts
Beta-klotho (KLB) is a protein from Homo sapiens identified by UniProt accession Q86Z14, 1044 residues long. MolForge cross-references it against 0 known binders and 237 disease associations.
- UniProt accession: Q86Z14; gene symbol KLB.
- Organism: Homo sapiens.
- Length: 1044 amino acids.
- Top disease associations (Open Targets): alcohol consumption measurement, congenital hypogonadotropic hypogonadism and alcohol use disorder measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-klotho |
|---|---|
| UniProt accession | Q86Z14 |
| Gene | KLB |
| Organism | Homo sapiens |
| Length | 1044 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (237)
Diseases linked to this target (Open Targets).
- alcohol consumption measurement · score 0.47
- congenital hypogonadotropic hypogonadism · score 0.46
- alcohol use disorder measurement · score 0.45
- longitudinal alcohol consumption measurement · score 0.40
- alcohol drinking · score 0.40
- cancer · score 0.38
- IGF-1 measurement · score 0.38
- serum gamma-glutamyl transferase measurement · score 0.36
- blood urea nitrogen measurement · score 0.35
- urate measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q86Z14-F1 | alphafold | PREDICTED | 89.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q86Z14.
Amino-acid sequence (1044 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLB?
The strongest Open Targets associations for KLB are alcohol consumption measurement, congenital hypogonadotropic hypogonadism, alcohol use disorder measurement, longitudinal alcohol consumption measurement and alcohol drinking.
How long is the KLB protein?
The Homo sapiens KLB protein (UniProt Q86Z14) is 1044 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q86Z14 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q86Z14 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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