WAP four-disulfide core domain protein 8 (WFDC8)
Homo sapiens — UniProt Q8IUA0
Data last refreshed: (UniProt release unknown)
Key facts
WAP four-disulfide core domain protein 8 (WFDC8) is a protein from Homo sapiens identified by UniProt accession Q8IUA0, 241 residues long. MolForge cross-references it against 0 known binders and 3 disease associations.
- UniProt accession: Q8IUA0; gene symbol WFDC8.
- Organism: Homo sapiens.
- Length: 241 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, depressive symptom measurement and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WAP four-disulfide core domain protein 8 |
|---|---|
| UniProt accession | Q8IUA0 |
| Gene | WFDC8 |
| Organism | Homo sapiens |
| Length | 241 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (3)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- depressive symptom measurement · score 0.02
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUA0-F1 | alphafold | PREDICTED | 87.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUA0.
Amino-acid sequence (241 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WFDC8?
The strongest Open Targets associations for WFDC8 are neurodegenerative disease, depressive symptom measurement and cancer.
How long is the WFDC8 protein?
The Homo sapiens WFDC8 protein (UniProt Q8IUA0) is 241 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUA0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUA0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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