Keratin-associated protein 8-1 (KRTAP8-1)
Homo sapiens — UniProt Q8IUC2
Data last refreshed: (UniProt release unknown)
Key facts
Keratin-associated protein 8-1 (KRTAP8-1) is a protein from Homo sapiens identified by UniProt accession Q8IUC2, 63 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q8IUC2; gene symbol KRTAP8-1.
- Organism: Homo sapiens.
- Length: 63 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, thyroid gland adenocarcinoma and generalised epilepsy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin-associated protein 8-1 |
|---|---|
| UniProt accession | Q8IUC2 |
| Gene | KRTAP8-1 |
| Organism | Homo sapiens |
| Length | 63 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- thyroid gland adenocarcinoma · score 0.16
- generalised epilepsy · score 0.12
- taxonomic microbiome measurement · score 0.05
- gut microbiome measurement · score 0.05
- colorectal adenocarcinoma · score 0.04
- breast carcinoma · score 0.03
- pancreatic adenocarcinoma · score 0.03
- lung adenocarcinoma · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUC2-F1 | alphafold | PREDICTED | 41.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUC2.
Amino-acid sequence (63 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRTAP8-1?
The strongest Open Targets associations for KRTAP8-1 are neurodegenerative disease, thyroid gland adenocarcinoma, generalised epilepsy, taxonomic microbiome measurement and gut microbiome measurement.
How long is the KRTAP8-1 protein?
The Homo sapiens KRTAP8-1 protein (UniProt Q8IUC2) is 63 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUC2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUC2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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