Keratin-associated protein 8-1 (KRTAP8-1)

About Keratin-associated protein 8-1

Keratin-associated protein 8-1 (KRTAP8-1) is a protein from Homo sapiens identified by UniProt accession Q8IUC2, 63 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Keratin-associated protein 8-1
UniProt accession	Q8IUC2
Gene	KRTAP8-1
Organism	Homo sapiens
Length	63 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
thyroid gland adenocarcinoma · score 0.16
generalised epilepsy · score 0.12
taxonomic microbiome measurement · score 0.05
gut microbiome measurement · score 0.05
colorectal adenocarcinoma · score 0.04
breast carcinoma · score 0.03
pancreatic adenocarcinoma · score 0.03
lung adenocarcinoma · score 0.01
neoplasm · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IUC2-F1	alphafold	PREDICTED	41.16	—

Amino-acid sequence (63 residues)

MLCDNFPGAV FPGCYWGSYG YPLGYSVGCG YGSTYSPVGY GFGYGYNGCG AFGYRRYSPF ALY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards