Rhophilin-2 (RHPN2)
Homo sapiens — UniProt Q8IUC4
Data last refreshed: (UniProt release unknown)
Key facts
Rhophilin-2 (RHPN2) is a protein from Homo sapiens identified by UniProt accession Q8IUC4, 686 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q8IUC4; gene symbol RHPN2.
- Organism: Homo sapiens.
- Length: 686 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, bone quantitative ultrasound measurement and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rhophilin-2 |
|---|---|
| UniProt accession | Q8IUC4 |
| Gene | RHPN2 |
| Organism | Homo sapiens |
| Length | 686 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.50
- bone quantitative ultrasound measurement · score 0.49
- alkaline phosphatase measurement · score 0.48
- colorectal cancer · score 0.47
- serum gamma-glutamyl transferase measurement · score 0.41
- lung adenocarcinoma · score 0.39
- bone density · score 0.38
- breast adenocarcinoma · score 0.37
- optic disc size measurement · score 0.33
- colorectal adenoma · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUC4-F1 | alphafold | PREDICTED | 82.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUC4.
Amino-acid sequence (686 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RHPN2?
The strongest Open Targets associations for RHPN2 are heel bone mineral density, bone quantitative ultrasound measurement, alkaline phosphatase measurement, colorectal cancer and serum gamma-glutamyl transferase measurement.
How long is the RHPN2 protein?
The Homo sapiens RHPN2 protein (UniProt Q8IUC4) is 686 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUC4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUC4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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