TIR domain-containing adapter molecule 1 (TICAM1)
Homo sapiens — UniProt Q8IUC6
Data last refreshed: (UniProt release unknown)
Key facts
TIR domain-containing adapter molecule 1 (TICAM1) is a protein from Homo sapiens identified by UniProt accession Q8IUC6, 712 residues long. MolForge cross-references it against 0 known binders and 229 disease associations.
- UniProt accession: Q8IUC6; gene symbol TICAM1.
- Organism: Homo sapiens.
- Length: 712 amino acids.
- Top disease associations (Open Targets): Herpetic encephalitis, inborn error of immunity and hypothyroidism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TIR domain-containing adapter molecule 1 |
|---|---|
| UniProt accession | Q8IUC6 |
| Gene | TICAM1 |
| Organism | Homo sapiens |
| Length | 712 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (229)
Diseases linked to this target (Open Targets).
- Herpetic encephalitis · score 0.64
- inborn error of immunity · score 0.38
- hypothyroidism · score 0.36
- basal cell carcinoma · score 0.35
- Thyroid preparation use measurement · score 0.34
- Vitiligo · score 0.28
- ulcer disease · score 0.28
- non-melanoma skin carcinoma · score 0.27
- keratinocyte carcinoma · score 0.27
- Oral ulcer · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUC6-F1 | alphafold | PREDICTED | 62.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUC6.
Amino-acid sequence (712 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TICAM1?
The strongest Open Targets associations for TICAM1 are Herpetic encephalitis, inborn error of immunity, hypothyroidism, basal cell carcinoma and Thyroid preparation use measurement.
How long is the TICAM1 protein?
The Homo sapiens TICAM1 protein (UniProt Q8IUC6) is 712 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUC6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUC6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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