E3 ubiquitin-protein ligase RNF135 (RNF135)
Homo sapiens — UniProt Q8IUD6
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF135 (RNF135) is a protein from Homo sapiens identified by UniProt accession Q8IUD6, 432 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q8IUD6; gene symbol RNF135.
- Organism: Homo sapiens.
- Length: 432 amino acids.
- Top disease associations (Open Targets): chromosome 17q11.2 deletion syndrome, 1.4Mb, autism spectrum disorder and BMI-adjusted hip circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF135 |
|---|---|
| UniProt accession | Q8IUD6 |
| Gene | RNF135 |
| Organism | Homo sapiens |
| Length | 432 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- chromosome 17q11.2 deletion syndrome, 1.4Mb · score 0.40
- autism spectrum disorder · score 0.34
- BMI-adjusted hip circumference · score 0.30
- pathological myopia · score 0.26
- breast adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.22
- appendicular lean mass · score 0.21
- urinary bladder cancer · score 0.20
- neurodegenerative disease · score 0.17
- Overgrowth - macrocephaly - facial dysmorphism · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUD6-F1 | alphafold | PREDICTED | 76.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUD6.
Amino-acid sequence (432 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF135?
The strongest Open Targets associations for RNF135 are chromosome 17q11.2 deletion syndrome, 1.4Mb, autism spectrum disorder, BMI-adjusted hip circumference, pathological myopia and breast adenocarcinoma.
How long is the RNF135 protein?
The Homo sapiens RNF135 protein (UniProt Q8IUD6) is 432 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUD6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUD6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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