Histone H2A type 2-B (H2AC21)
Homo sapiens — UniProt Q8IUE6
Data last refreshed: (UniProt release unknown)
Key facts
Histone H2A type 2-B (H2AC21) is a protein from Homo sapiens identified by UniProt accession Q8IUE6, 130 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q8IUE6; gene symbol H2AC21.
- Organism: Homo sapiens.
- Length: 130 amino acids.
- Top disease associations (Open Targets): infectious disease, viral disease and breast carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone H2A type 2-B |
|---|---|
| UniProt accession | Q8IUE6 |
| Gene | H2AC21 |
| Organism | Homo sapiens |
| Length | 130 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- infectious disease · score 0.50
- viral disease · score 0.50
- breast carcinoma · score 0.06
- sebaceous of Jadassohn nevus · score 0.05
- actinic keratosis · score 0.05
- triglyceride measurement · score 0.04
- lymphocyte percentage of leukocytes · score 0.03
- bilirubin measurement · score 0.02
- sex hormone-binding globulin measurement · score 0.02
- serum urea measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUE6-F1 | alphafold | PREDICTED | 90.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUE6.
Amino-acid sequence (130 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with H2AC21?
The strongest Open Targets associations for H2AC21 are infectious disease, viral disease, breast carcinoma, sebaceous of Jadassohn nevus and actinic keratosis.
How long is the H2AC21 protein?
The Homo sapiens H2AC21 protein (UniProt Q8IUE6) is 130 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUE6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUE6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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