Zinc-regulated GTPase metalloprotein activator 1B (ZNG1B)
Homo sapiens — UniProt Q8IUF1
Data last refreshed: (UniProt release unknown)
Key facts
Zinc-regulated GTPase metalloprotein activator 1B (ZNG1B) is a protein from Homo sapiens identified by UniProt accession Q8IUF1, 395 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q8IUF1; gene symbol ZNG1B.
- Organism: Homo sapiens.
- Length: 395 amino acids.
- Top disease associations (Open Targets): sleep duration, insomnia measurement and circadian rhythm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc-regulated GTPase metalloprotein activator 1B |
|---|---|
| UniProt accession | Q8IUF1 |
| Gene | ZNG1B |
| Organism | Homo sapiens |
| Length | 395 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- sleep duration · score 0.20
- insomnia measurement · score 0.15
- circadian rhythm · score 0.12
- excessive daytime sleepiness measurement · score 0.12
- insomnia · score 0.11
- congenital hydronephrosis · score 0.07
- ureteral neoplasm · score 0.07
- ureter cancer · score 0.07
- ureterocele · score 0.07
- familial vesicoureteral reflux · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUF1-F1 | alphafold | PREDICTED | 75.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUF1.
Amino-acid sequence (395 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNG1B?
The strongest Open Targets associations for ZNG1B are sleep duration, insomnia measurement, circadian rhythm, excessive daytime sleepiness measurement and insomnia.
How long is the ZNG1B protein?
The Homo sapiens ZNG1B protein (UniProt Q8IUF1) is 395 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUF1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUF1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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