Unconventional myosin-XVIIIb (MYO18B)

Homo sapiens — UniProt Q8IUG5

Gene: MYO18BHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Unconventional myosin-XVIIIb (MYO18B) is a protein from Homo sapiens identified by UniProt accession Q8IUG5, 2567 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.

UniProt accession: Q8IUG5; gene symbol MYO18B.
Organism: Homo sapiens.
Length: 2567 amino acids.
Top disease associations (Open Targets): Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome, electrocardiography and mathematical ability.
3D structure: AlphaFold model available.

Target properties

Protein name	Unconventional myosin-XVIIIb
UniProt accession	Q8IUG5
Gene	MYO18B
Organism	Homo sapiens
Length	2567 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (98)

Diseases linked to this target (Open Targets).

Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome · score 0.78
electrocardiography · score 0.50
mathematical ability · score 0.41
Cluster headache · score 0.33
PHF-tau measurement · score 0.33
left ventricular structural measurement · score 0.32
Left ventricular mass to end-diastolic volume ratio · score 0.32
gut microbiome measurement · score 0.32
Brugada syndrome · score 0.31
neurofibrillary tangles measurement · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IUG5-F1	alphafold	PREDICTED	59.76	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUG5.

Amino-acid sequence (2567 residues)

MAISSRLALW EQKIREEDKS PPPSSPPPLF SVIPGGFIKQ LVRGTEKEAK EARQRKQLAV ASPEREIPEI SISQPNSKSS SGTRSGSQQI SQDDQSSSPG SSDILGKESE GSRSPDPEQM TSINGEKAQE LGSSATPTKK TVPFKRGVRR GDVLLMVAKL DPDSAKPEKT HPHDAPPCKT SPPATDTGKE KKGETSRTPC GSQASTEILA PKAEKTRTGG LGDPGQGTVA LKKGEEGQSI VGKGLGTPKT TELKEAEPQG KDRQGTRPQA QGPGEGVRPG KAEKEGAEPT NTVEKGNVSK DVGSEGKHVR PQIPGRKWGG FLGRRSKWDG PQNKKDKEGV LLSKAEKTGE PQTQMEKTSQ VQGELGDDLR MGEKAGELRS TTGKAGESWD KKEKMGQPQG KSGNAGEARS QTEKGCEAPK EVSTMVESPA APGKGGWPGS RGQEAEEPCS RAGDGAGALE TELEGPSQPA LEKDAERPRI RKENQDGPAP QEEGKGGQSR DSDQAPEDRW YEAEKVWLAQ KDGFTLATVL KPDEGTADLP AGRVRLWIDA DKTITEVDEE HVHRANPPEL DQVEDLASLI SVNESSVLNT LLQRYKAQLL HTCTGPDLIV LQPRGPSVPS AGKVPKGRRD GLPAHIGSMA QRAYWALLNQ RRDQSIVALG WSGAGKTTCC EQVLEHLVGM AGSVDGRVSV EKIRATFTVL RAFGSVSMAH SRSATRFSMV MSLDFNATGR ITAAQLQTML LEKSRVARQP EGESNFLVFS QMLAGLDLDL RTELNLHQMA DSSSFGMGVW SKPEDKQKAA AAFAQLQGAM EMLGISESEQ RAVWRVLAAI YHLGAAGACK VGRKQFMRFE WANYAAEALG CEYEELNTAT FKHHLRQIIQ QMTFGPSRWG LEDEETSSGL KMTGVDCVEG MASGLYQELF AAVVSLINRS FSSHHLSMAS IMVVDSPGFQ NPRHQGKDRA ATFEELCHNY AHERLQLLFY QRTFVSTLQR YQEEGVPVQF DLPDPSPGTT VAVVDQNPSQ VRLPAGGGAQ DARGLFWVLD EEVHVEGSSD SVVLERLCAA FEKKGAGTEG SSALRTCEQP LQCEIFHQLG WDPVRYDLTG WLHRAKPNLS ALDAPQVLHQ SKREELRSLF QARAKLPPVC RAVAGLEGTS QQALQRSRMV RRTFASSLAA VRRKAPCSQI KLQMDALTSM IKRSRLHFIH CLVPNPVVES RSGQESPPPP QPGRDKPGAG GPLALDIPAL RVQLAGFHIL EALRLHRTGY ADHMGLTRFR RQFQVLDAPL LKKLMSTSEG IDERKAVEEL LETLDLEKKA VAVGHSQVFL KAGVISRLEK QREKLVSQSI VLFQAACKGF LSRQEFKKLK IRRLAAQCIQ KNVAVFLAVK DWPWWQLLGS LQPLLSATIG TEQLRAKEEE LTTLRRKLEK SEKLRNELRQ NTDLLESKIA DLTSDLADER FKGDVACQVL ESERAERLQA FREVQELKSK HEQVQKKLGD VNKQLEEAQQ KIQLNDLERN PTGGADEWQM RFDCAQMENE FLRKRLQQCE ERLDSELTAR KELEQKLGEL QSAYDGAKKM AHQLKRKCHH LTCDLEDTCV LLENQQSRNH ELEKKQKKFD LQLAQALGES VFEKGLREKV TQENTSVRWE LGQLQQQLKQ KEQEASQLKQ QVEMLQDHKR ELLGSPSLGE NCVAGLKERL WKLESSALEQ QKIQSQQENT IKQLEQLRQR FELEIERMKQ MHQKDREDQE EELEDVRQSC QKRLHQLEMQ LEQEYEEKQM VLHEKQDLEG LIGTLCDQIG HRDFDVEKRL RRDLRRTHAL LSDVQLLLGT MEDGKTSVSK EELEKVHSQL EQSEAKCEEA LKTQKVLTAD LESMHSELEN MTRNKSLVDE QLYRLQFEKA DLLKRIDEDQ DDLNELMQKH KDLIAQSAAD IGQIQELQLQ LEEAKKEKHK LQEQLQVAQM RIEYLEQSTV DRAIVSRQEA VICDLENKTE FQKVQIKRFE VLVIRLRDSL IKMGEELSQA ATSESQQRES SQYYQRRLEE LKADMEELVQ REAEASRRCM ELEKYVEELA AVRQTLQTDL ETSIRRIADL QAALEEVASS DSDTESVQTA VDCGSSGRKE MDNVSILSSQ PEGSLQSWLS CTLSLATDTM RTPSRQSATS SRILSPRINE EAGDTERTQS ALALSRARST NVHSKTSGDK PVSPHFVRRQ KYCHFGDGEV LAVQRKSTER LEPASSPLAS RSTNTSPLSR EKLPSPSAAL SEFVEGLRRK RAQRGQGSTL GLEDWPTLPI YQTTGASTLR RGRAGSDEGN LSLRVGAKSP LEIEGAAGGL LRSTSLKCIS SDGVGGTTLL PEKSKTQFSS CESLLESRPS MGRKLSSPTT PRDMLLSPTL RPRRRCLESS VDDAGCPDLG KEPLVFQNRQ FAHLMEEPLG SDPFSWKLPS LDYERKTKVD FDDFLPAIRK PQTPTSLAGS AKGGQDGSQR SSIHFETEEA NRSFLSGIKT ILKKSPEPKE DPAHLSDSSS SSGSIVSFKS ADSIKSRPGI PRLAGDGGER TSPERREPGT GRKDDDVASI MKKYLQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with MYO18B?

The strongest Open Targets associations for MYO18B are Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome, electrocardiography, mathematical ability, Cluster headache and PHF-tau measurement.

How long is the MYO18B protein?

The Homo sapiens MYO18B protein (UniProt Q8IUG5) is 2567 amino acids long.

Browse: Targets: M · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q8IUG5 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q8IUG5 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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