Signal peptide peptidase-like 2C (SPPL2C)
Homo sapiens — UniProt Q8IUH8
Data last refreshed: (UniProt release unknown)
Key facts
Signal peptide peptidase-like 2C (SPPL2C) is a protein from Homo sapiens identified by UniProt accession Q8IUH8, 684 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.
- UniProt accession: Q8IUH8; gene symbol SPPL2C.
- Organism: Homo sapiens.
- Length: 684 amino acids.
- Top disease associations (Open Targets): Parkinson disease, total cortical area measurement and BMI-adjusted waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Signal peptide peptidase-like 2C |
|---|---|
| UniProt accession | Q8IUH8 |
| Gene | SPPL2C |
| Organism | Homo sapiens |
| Length | 684 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (142)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.27
- total cortical area measurement · score 0.25
- BMI-adjusted waist-hip ratio · score 0.23
- waist-hip ratio · score 0.22
- idiopathic pulmonary fibrosis · score 0.21
- mean corpuscular volume · score 0.19
- alkaline phosphatase measurement · score 0.19
- aspartate aminotransferase measurement · score 0.19
- white matter microstructure measurement · score 0.19
- osteoarthritis · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUH8-F1 | alphafold | PREDICTED | 67.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUH8.
Amino-acid sequence (684 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPPL2C?
The strongest Open Targets associations for SPPL2C are Parkinson disease, total cortical area measurement, BMI-adjusted waist-hip ratio, waist-hip ratio and idiopathic pulmonary fibrosis.
How long is the SPPL2C protein?
The Homo sapiens SPPL2C protein (UniProt Q8IUH8) is 684 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUH8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUH8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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