Cerebellin-2 (CBLN2)
Homo sapiens — UniProt Q8IUK8
Data last refreshed: (UniProt release unknown)
Key facts
Cerebellin-2 (CBLN2) is a protein from Homo sapiens identified by UniProt accession Q8IUK8, 224 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q8IUK8; gene symbol CBLN2.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): protein measurement, bilirubin measurement and pulmonary arterial hypertension.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cerebellin-2 |
|---|---|
| UniProt accession | Q8IUK8 |
| Gene | CBLN2 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.36
- bilirubin measurement · score 0.34
- pulmonary arterial hypertension · score 0.24
- rheumatic disease · score 0.22
- schizophrenia · score 0.12
- FEV/FVC ratio · score 0.07
- central nervous system cancer · score 0.04
- glioblastoma multiforme · score 0.04
- adolescent idiopathic scoliosis · score 0.03
- systemising measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUK8-F1 | alphafold | PREDICTED | 75.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUK8.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CBLN2?
The strongest Open Targets associations for CBLN2 are protein measurement, bilirubin measurement, pulmonary arterial hypertension, rheumatic disease and schizophrenia.
How long is the CBLN2 protein?
The Homo sapiens CBLN2 protein (UniProt Q8IUK8) is 224 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUK8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUK8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.