E3 ubiquitin-protein ligase SIAH1 (SIAH1)
Homo sapiens — UniProt Q8IUQ4
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase SIAH1 (SIAH1) is a protein from Homo sapiens identified by UniProt accession Q8IUQ4, 282 residues long. MolForge cross-references it against 0 known binders and 198 disease associations.
- UniProt accession: Q8IUQ4; gene symbol SIAH1.
- Organism: Homo sapiens.
- Length: 282 amino acids.
- Top disease associations (Open Targets): Buratti-Harel syndrome, Neurodevelopmental disorder and Global developmental delay.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase SIAH1 |
|---|---|
| UniProt accession | Q8IUQ4 |
| Gene | SIAH1 |
| Organism | Homo sapiens |
| Length | 282 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (198)
Diseases linked to this target (Open Targets).
- Buratti-Harel syndrome · score 0.60
- Neurodevelopmental disorder · score 0.44
- Global developmental delay · score 0.37
- Laryngomalacia · score 0.37
- Infantile muscular hypotonia · score 0.37
- complex neurodevelopmental disorder · score 0.37
- bone density · score 0.25
- urate measurement · score 0.25
- genetic disorder · score 0.17
- mean corpuscular hemoglobin · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUQ4-F1 | alphafold | PREDICTED | 89.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUQ4.
Amino-acid sequence (282 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIAH1?
The strongest Open Targets associations for SIAH1 are Buratti-Harel syndrome, Neurodevelopmental disorder, Global developmental delay, Laryngomalacia and Infantile muscular hypotonia.
How long is the SIAH1 protein?
The Homo sapiens SIAH1 protein (UniProt Q8IUQ4) is 282 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUQ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUQ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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