Protein O-mannosyl-transferase TMTC1 (TMTC1)
Homo sapiens — UniProt Q8IUR5
Data last refreshed: (UniProt release unknown)
Key facts
Protein O-mannosyl-transferase TMTC1 (TMTC1) is a protein from Homo sapiens identified by UniProt accession Q8IUR5, 882 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q8IUR5; gene symbol TMTC1.
- Organism: Homo sapiens.
- Length: 882 amino acids.
- Top disease associations (Open Targets): schizophrenia, metabolite measurement and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein O-mannosyl-transferase TMTC1 |
|---|---|
| UniProt accession | Q8IUR5 |
| Gene | TMTC1 |
| Organism | Homo sapiens |
| Length | 882 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.43
- metabolite measurement · score 0.31
- platelet count · score 0.09
- mean platelet volume · score 0.08
- platelet component distribution width · score 0.08
- mitochondrial DNA measurement · score 0.04
- platelet-to-lymphocyte ratio · score 0.04
- glioblastoma multiforme · score 0.02
- esophageal squamous cell carcinoma · score 0.02
- neoplasm · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUR5-F1 | alphafold | PREDICTED | 87.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUR5.
Amino-acid sequence (882 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMTC1?
The strongest Open Targets associations for TMTC1 are schizophrenia, metabolite measurement, platelet count, mean platelet volume and platelet component distribution width.
How long is the TMTC1 protein?
The Homo sapiens TMTC1 protein (UniProt Q8IUR5) is 882 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUR5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUR5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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