CREB3 regulatory factor (CREBRF)
Homo sapiens — UniProt Q8IUR6
Data last refreshed: (UniProt release unknown)
Key facts
CREB3 regulatory factor (CREBRF) is a protein from Homo sapiens identified by UniProt accession Q8IUR6, 639 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q8IUR6; gene symbol CREBRF.
- Organism: Homo sapiens.
- Length: 639 amino acids.
- Top disease associations (Open Targets): platelet count, PR interval and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CREB3 regulatory factor |
|---|---|
| UniProt accession | Q8IUR6 |
| Gene | CREBRF |
| Organism | Homo sapiens |
| Length | 639 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- platelet count · score 0.40
- PR interval · score 0.39
- body height · score 0.34
- lean body mass · score 0.30
- self reported educational attainment · score 0.29
- pulse pressure measurement · score 0.29
- cystatin C measurement · score 0.28
- body mass index · score 0.27
- infantile hypertrophic pyloric stenosis · score 0.25
- open-angle glaucoma · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUR6-F1 | alphafold | PREDICTED | 56.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUR6.
Amino-acid sequence (639 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CREBRF?
The strongest Open Targets associations for CREBRF are platelet count, PR interval, body height, lean body mass and self reported educational attainment.
How long is the CREBRF protein?
The Homo sapiens CREBRF protein (UniProt Q8IUR6) is 639 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUR6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUR6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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