Armadillo repeat-containing protein 8 (ARMC8)
Homo sapiens — UniProt Q8IUR7
Data last refreshed: (UniProt release unknown)
Key facts
Armadillo repeat-containing protein 8 (ARMC8) is a protein from Homo sapiens identified by UniProt accession Q8IUR7, 673 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q8IUR7; gene symbol ARMC8.
- Organism: Homo sapiens.
- Length: 673 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, percutaneous transluminal coronary angioplasty and osteosarcoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Armadillo repeat-containing protein 8 |
|---|---|
| UniProt accession | Q8IUR7 |
| Gene | ARMC8 |
| Organism | Homo sapiens |
| Length | 673 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- percutaneous transluminal coronary angioplasty · score 0.09
- osteosarcoma · score 0.08
- urinary bladder carcinoma · score 0.07
- mean corpuscular volume · score 0.07
- mathematical ability · score 0.04
- cognitive function measurement · score 0.03
- neoplasm · score 0.03
- melanoma · score 0.03
- mean reticulocyte volume · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUR7-F1 | alphafold | PREDICTED | 94.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUR7.
Amino-acid sequence (673 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARMC8?
The strongest Open Targets associations for ARMC8 are neurodegenerative disease, percutaneous transluminal coronary angioplasty, osteosarcoma, urinary bladder carcinoma and mean corpuscular volume.
How long is the ARMC8 protein?
The Homo sapiens ARMC8 protein (UniProt Q8IUR7) is 673 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUR7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUR7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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