Spermatogenesis-associated protein 2-like protein (SPATA2L)
Homo sapiens — UniProt Q8IUW3
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis-associated protein 2-like protein (SPATA2L) is a protein from Homo sapiens identified by UniProt accession Q8IUW3, 424 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q8IUW3; gene symbol SPATA2L.
- Organism: Homo sapiens.
- Length: 424 amino acids.
- Top disease associations (Open Targets): white matter microstructure measurement, cigarettes per day measurement and hair color.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis-associated protein 2-like protein |
|---|---|
| UniProt accession | Q8IUW3 |
| Gene | SPATA2L |
| Organism | Homo sapiens |
| Length | 424 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- white matter microstructure measurement · score 0.25
- cigarettes per day measurement · score 0.14
- hair color · score 0.11
- puberty onset measurement · score 0.10
- glomerular filtration rate · score 0.10
- age at first facial hair · score 0.09
- hair morphology measurement · score 0.09
- hair colour measurement · score 0.09
- mean corpuscular volume · score 0.09
- facial pigmentation measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUW3-F1 | alphafold | PREDICTED | 72.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUW3.
Amino-acid sequence (424 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPATA2L?
The strongest Open Targets associations for SPATA2L are white matter microstructure measurement, cigarettes per day measurement, hair color, puberty onset measurement and glomerular filtration rate.
How long is the SPATA2L protein?
The Homo sapiens SPATA2L protein (UniProt Q8IUW3) is 424 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUW3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUW3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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