GRAM domain-containing protein 2A (GRAMD2A)
Homo sapiens — UniProt Q8IUY3
Data last refreshed: (UniProt release unknown)
Key facts
GRAM domain-containing protein 2A (GRAMD2A) is a protein from Homo sapiens identified by UniProt accession Q8IUY3, 354 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q8IUY3; gene symbol GRAMD2A.
- Organism: Homo sapiens.
- Length: 354 amino acids.
- Top disease associations (Open Targets): body height, sitting height measurement and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GRAM domain-containing protein 2A |
|---|---|
| UniProt accession | Q8IUY3 |
| Gene | GRAMD2A |
| Organism | Homo sapiens |
| Length | 354 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- body height · score 0.59
- sitting height measurement · score 0.46
- lean body mass · score 0.41
- forced expiratory volume · score 0.23
- appendicular lean mass · score 0.19
- brain measurement · score 0.17
- vital capacity · score 0.15
- erythrocyte count · score 0.14
- urate measurement · score 0.13
- body weights and measures · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IUY3-F1 | alphafold | PREDICTED | 63.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IUY3.
Amino-acid sequence (354 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GRAMD2A?
The strongest Open Targets associations for GRAMD2A are body height, sitting height measurement, lean body mass, forced expiratory volume and appendicular lean mass.
How long is the GRAMD2A protein?
The Homo sapiens GRAMD2A protein (UniProt Q8IUY3) is 354 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IUY3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IUY3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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